Method and apparatus for measuring continuous blood flow at low power

ABSTRACT

A technique for determining blood flow in a living body by changing the thermal energy level by a predetermined amount at a site in a blood flow path and detecting temperatures at locations upstream and downstream of the site. The temperature difference at such locations is determined and the blood flow is calculated as a function of the change in energy level and of the temperature differences measured prior to and following the change in energy level.

This application is a divisional of U.S. Ser. No. 08/106,068, filed Aug. 13, 1993.

INTRODUCTION

This invention relates generally to techniques for measuring blood flow in a body and, more particularly, to the use preferably of one or more temperature sensors for measuring thermal energy changes in the blood flowing through the heart and to the use of unique data processing techniques in response thereto for determining cardiac output.

BACKGROUND OF THE INVENTION

While the invention can be used generally to measure blood flow at various locations in a body, it is particularly useful in measuring blood flow in the heart so as to permit the measurement of cardiac output. Many techniques for measuring cardiac output have been suggested in the art. Exemplary thermodilution techniques described in the technical and patent literature include: "A Continuous Cardiac Output Computer Based On Thermodilution Principles", Normann et al., Annals of Biomedical Engineering, Vol. 17, 1989; "Thermodilution Cardiac Output Determination With A single Flow-Directed Catheter", Forrester, et al., American Heart Journal, Vol. 83, No. 3, 1972; "Understanding Techniques for Measuring Cardiac Output", Taylor, et al., Biomedical Instrumentation & Technology, May/June 1990; U.S. Pat. No. 4,507,974 of M. L. Yelderman, issued Apr. 2, 1985; U.S. Pat. No. 4,785,823, of Eggers et al., issued on Nov. 22, 1988; and U.S. Pat. No. 5,000,190, of John H. Petre, issued on Mar. 19, 1991.

A principal limitation in the quanification of cardiac output is the existence of thermal fluctuations inherent in the bloodstream. Previous methods work with those fluctuations while observing the effects of an input signal to calculate cardiac output. The invention described herein uses a differential measurement technique to substantially eliminate the effect of the thermal fluctuations, permitting the use of a minimal thermal input signal, which allows frequent or continuous measurements.

It is desirable to obtain accurate cardiac output measurements in an effectively continuous manner, i.e., several times a minute, so that a diagnosis can be achieved more rapidly and sot hat rapid changes in a patient's condition can be monitored on a more continuous basis than is possible using current techniques. Moreover, it is desirable to obtain instantaneous measurements of the cardiac output on a beat-to-beat basis to evaluate the relative changes which occur from beat to beat, as well as to determine the presence of regurgitation.

BRIEF SUMMARY OF THE INVENTION

In accordance with general principal of the invention, blood flow and/or cardiac output is determined rapidly, using a technique by which an indicator substance, or agent, is introduced into the bloodstream between a pair of detectors. The detectors are sensitive to a parameter functionally related to the concentration or magnitude in the bloodstream of the selected indicator agent. The detectors are positioned apart by a distance functionally sufficient to allow a measurement to be made of the differential value of the selected parameter as it exists from time-to-time between the two detectors. The indicator agent, for example, may be a substance to change the pH of the blood, a fluid bolus carrying thermal energy, or a substance to change a selected characteristic of the blood, or the direct introduction of thermal energy, or the like.

A determination is made of the difference in the values of the selected blood parameter as it exists at the two detectors, prior to the introduction of indicator agent (i.e., the first differential value). The selected indicator agent is then introduced in a predetermined magnitude. Then again a determination is made of the difference in values of the selected parameter as it exists at the locations of the two detectors (i.e., the second differential value).

Blood flow or cardiac output, depending on the specific location of the detectors, can then be determined as a function of the difference between the first differential value and the second differential value. Because the ultimate measurement of blood flow or cardiac output is based on the difference of the differences, the system operates effectively with the introduction of the indicator agent in a very low magnitude. In turn, this allows measurements to be made rapidly so that effectively continuous measurements are obtained.

In accordance with a preferred embodiment of the invention, for example, cardiac output can be determined rapidly and with low levels of thermal energy input. To achieve such operation, in a preferred embodiment, the technique of the invention uses a pair of temperature sensors positioned at two selected locations within a catheter which has been inserted into the path of the blood flowing through the heart of a living body. The, sensors detect the temperature difference between the two locations. Depending on the location of the temperature sensors in the circulatory system, the measured temperature difference varies over time. It has been observed that when the temperature sensors are placed within the heart, e.g., so that one sensor lies in the vena cava, for example, and the second in the right ventricle or pulmonary artery, the temperature difference varies in a synchronous manner with the respiratory cycle.

Thus, in the preferred embodiment of the invention the temperature difference over at least one respiratory cycle is measured and averaged to provide an average temperature difference. The averaging, or integrating, action effectively eliminates, as a confounding factor in the determination of cardiac output, the effect of instantaneous blood temperature fluctuations, such as cyclical, respiratory-induced fluctuations.

To make such determinations, an average temperature difference is first calculated over a time period of at least one respiratory cycle in which no thermal energy is introduced into the blood flow path. Thermal energy of a predetermined and relatively low magnitude is then introduced into the blood flow path to produce a heating action therein at a location between the two temperature sensors. Once the temperature rise induced by the heating stabilizes, the average temperature difference between the two locations is again calculated from temperature difference measurements over a time period of at least one respiratory cycle at the higher temperature level. The difference between the average temperature differences which occurs when the thermal energy is turned on, referred to as the rising temperature change, is determined. The difference between the average temperature differences which occurs when the thermal energy is turned off, referred to as the falling temperature change, is similarly determined. The cardiac output is calculated as a function of the thermal energy input and the rising and falling temperature changes. Because a relatively low level of thermal energy is used in making measurements, the overall sequence of determinations can be safely repeated multiple times per minute, for example, so that an effectively continuous, or quasi-continuous, determination of cardiac output is obtained.

In accordance with a further embodiment of the invention, a temperature sensor that also acts as a source of thermal energy, e.g., a thermistor, is positioned at a third location in the cardiac blood flow path. Power is supplied to the sensor sufficient to elevate the temperature of the sensor from a first temperature level to a second temperature level. In one embodiment of the invention, the temperature of the sensor is changed from the first to the second level and is maintained constant at said second level by varying the power that is supplied thereto. Such varying power is proportional to the instantaneous flow velocity and, hence, assuming a constant flow area, is proportional to the instantaneous cardiac output. Measurement of the sensor heating power and the temperature increment at the sensor can thus be used to continuously effect a determination of the instantaneous cardiac output. Further, for example, when the sensor is placed downstream at the outlet of one of the heart chambers, the variation in flow output over the cardiac cycle can be analyzed to provide an indication of the regurgitation characteristics of the heart outlet valve over the cardiac cycle. Moreover, such instantaneous cardiac output determination can be further refined to compensate for fluctuations in the temperature of the blood flowing through the heart by measuring the instantaneous temperature of the blood with another temperature sensor at a nearby location and appropriately taking into account such temperature variations when determining the cardiac output.

In another application, both the continuous cardiac output determinations and the instantaneous cardiac output determinations, as described above, can be combined. Thus, three temperature sensors and a source of thermal energy can all be used in combination to simultaneously provide an accurate and effectively continuous determination of time-averaged cardiac output, and a determination of instantaneous cardiac output at each instant of the cardiac cycle in still another application, two temperature sensors and a source of thermal energy can be used in an appropriate sequence to provide the averaged cardiac output determination and the instantaneous cardiac output determination.

DESCRIPTION OF THE INVENTION

The invention can be described in more detail with the help of the accompanying drawings wherein

FIG. 1 shows a simplified diagrammatic view of a human heart;

FIG. 2 shows a simplified diagrammatic view of a catheter useful in the invention;

FIG. 3 shows a flow chart depicting steps in a process used in the invention;

FIG. 3A shows a smooth temperature difference curve obtained in the process depicted in FIG. 3;

FIG. 4 shows a flow chart depicting further steps in a process used in the invention;

FIG. 5 shows a flow chart depicting still further steps in a process of the invention;

FIG. 6 shows a graph depicting a temperature/time relation used in the invention;

FIG. 7A shows a simplified diagrammatic view of another catheter used in the invention;

FIG. 7B shows a flow chart depicting steps in still another process of the invention;

FIGS. 8A, 8B and 8C show flow charts depicting modes of operating the process of the invention;

FIGS. 9A, 9B, and 9C show graphs of parameter relationships used in the invention; and

FIG. 10 shows a graph useful for calibrating the flow values for a catheter used in the invention.

As can be seen in FIG. 1, which represents a human heart 10 in a much simplified diagrammatic form, a flexible catheter 11 is inserted through the veins into the right atrium, or auricle, 12 of the heart and, thence, through the right ventricle 13 until the end of the catheter resides in or near the exit, or pulmonary, artery 14 which leads to the lungs. As is well known, blood flows (as represented by the arrows) from the input vein 15, i.e., the vena cava, into the right atrium and right ventricle and thence outwardly to the lungs and subsequently returns from the lungs into the left atrium 16, through the left ventricle 17 and thence outwardly into the aorta 18.

In accordance with the embodiment of the invention, shown with reference to FIG. 1, temperature sensors, e.g., thermistors, are carried by the catheter so that, when inserted as shown in FIG. 1, a first sensor 19 is positioned at a location within the vena cava 15 or right atrium 12 and a second sensor 20 is positioned at a location in or near the pulmonary artery 14.

For simplicity, the flexible catheter 11 is depicted in FIG. 2 in an extended condition with temperature sensors 19 and 20 at two different locations for measuring temperatures T₁ and T₂, respectively. A power source 21 of thermal energy which is borne, or carried, by the catheter 11 is positioned in the right atrium at a location between sensors 19 and 20. In a particular embodiment, the catheter-borne source is, for example, a coil of resistive wire placed on or embedded in the surface of catheter 11, to which an AC or a DC voltage (not shown) at a controllable level is supplied so as to generate thermal energy, i.e. heat. The magnitude of the thermal energy can be suitably controlled to insert a predetermined amount of thermal energy at a selected time, which thermal energy is transferred to the blood flowing through the heart so as to raise its temperature. The energy source is positioned at a sufficient distance from the sensor 19 that the latter is effectively thermally isolated from the site of the thermal energy source.

While the locations of the sensors 19 and 20 and the energy source 21 can be as shown in FIG. 1, alternative locations can also be used. Thus, the sensor 19 can be positioned in the vena cava 15, while the energy source 21 is located in the right atrium 12 and the sensor 20 in either the right atrium or the right ventricle. Moreover, if sensor 19 is positioned in the vena cava 15, the entire energy source 21, which is normally elongated, need not be located in the right atrium and can have a portion thereof in the vena cava and a portion thereof in the right atrium. Such source should preferably be at least partially located in the right atrium. Further, sensor 20 may be positioned in the right ventricle near the pulmonary artery 14 or may be located in the pulmonary artery itself at or near the right ventricle.

The temperatures T₁ and T₂ at locations 19 and 20 upstream and downstream, respectively, from the thermal energy source 21 are monitored and processed appropriately by a digital microprocessor. In accordance with the invention, the instantaneous temperatures are obtained as the outputs T₁ (t) and T₂ (t) of the temperature sensors 19 and 20, respectively. The outputs are connected to a differential amplifier to generate an analog signal which is proportional to the temperature difference ΔT(t)=T₁ (t)-T₂ (t) between them. The temperature difference signal ΔT(t) is digitized and sampled at selected time intervals by an analog-to-digital/sampling circuit. The digitized sampled temperature difference values and the known thermal energy values are supplied to a digital microprocessor which then suitably processes the data to provide the desired cardiac output information. The processing stages used in the host microprocessor are implemented by suitable programming of the microprocessor and are discussed below with the help of FIGS. 3-6.

The source 21 of thermal energy is alternately turned on and off. If it is assumed that thermal stability is reached after each change and that there is a substantially constant rate of blood flow, a stable temperature difference can be measured in each case. The quantity of blood flowing past the thermal energy source, i.e., the cardiac output, can be derived from such temperature difference measurements. However, such derivation is complicated by two factors which may affect the measurement of blood flow. First, the rate of blood flow through the heart is not substantially constant but surges with each heart contraction. Second, the temperature of the blood flowing through the heart is not constant but varies with each respiratory (breathing) cycle. In a preferred embodiment, the processing of the data takes such factors into account, as discussed below.

The process for determining cardiac output is performed in a microprocessor 2 which in a first embodiment is programmed to respond to the temperatures sensed at T₁ and T₂ and to perform the steps depicted in accordance with the flow charts shown in FIGS. 3-5. From a knowledge of such flow charts, it would be well within the skill of those in the art to appropriately program any suitable and known digital microprocessor, such as a personal computer, to perform the steps shown.

FIG. 3 depicts a basic process, identified as Process I, which is used in the overall processing of temperature data for determining cardiac output, as subsequently depicted in FIGS. 4 and 5. In the basic process shown in FIG. 3, a temperature difference as a function of time ΔT(t) is determined by a differential amplifier which responds to T₁ (t) and T₂ (t). Such differences may be effectively smoothed, or filtered, to produce a smooth temperature difference curve, as shown in FIG. 3A, which varies as a function of time in a cyclic manner which depends principally on the respiratory cycle of the person whose cardiac output is being determined.

The periods τ₁, τ₂ . . . τ_(n) for each respiratory cycle are determined over n cycles. A characteristic of the temperature difference at each cycle is determined. For example, such characteristic preferably is the averaged temperature difference during each cycle (ΔT.sub.τ1, ΔT.sub.τ2 . . . ΔT.sub.τs . . . ΔT.sub.τn).

(Alternatively, for example, the peak temperature differences may be the determined characteristic.) These averaged temperature differences (ΔT.sub.τn) are added for the n cycles involved and are divided by n to determine an averaged temperature difference per cycle (ΔT.sub.τn). The use of Process I is depicted in the process steps shown in FIG. 4, identified as Process II.

As seen therein, the steps of Process I are first performed when the source 21 of thermal energy (i.e., a heater) is turned off and the average ΔT_(off) value per cycle is determined and suitably stored. The sampling time at which such determination is made is depicted in FIG. 6 as the sample time period S1.

The heater 21 is then turned on for a specific time period to supply a known amount of power P to the blood flowing through the heart and, accordingly, the temperature of the blood flowing past the heater rises and the temperature difference ΔT(t) rises over a transition, or delay, rise time period, t_(R1), shown in FIG. 6 and designated as D1, after which the temperature difference generally stabilizes over a second sample time period S2. As seen in FIG. 4, after the heater 21 is turned on and the temperature has stabilized, Process I is performed, again over n cycles, e.g., over the time period S2, and the averaged temperature difference ΔT_(on) is determined with the heater turned on and is suitably stored. The heater is then turned off and the temperature falls over a transition, or delay, fall time period t_(F1), shown in FIG. 6 and designated as D2, generally to its former value.

Cardiac output is calculated using the averaged temperature differences when the energy is off and the averaged temperature differences when the energy is on, by the relationship: ##EQU1## where: F=Flow

P=Power

C_(p) =heat capacitance

ΔT_(on) =average temperature for power on

ΔT_(off) =average temperature for power off

As seen in FIG. 5, the steps of Process II are repeated indefinitely for N data collection cycles, a data collection cycle being designated as including the time periods S1, D1, S2, and D2, as shown in FIG. 6. For each data collection cycle the rise time temperature difference ΔT_(R) between the averaged temperature difference ΔT_(on) at S2 and the averaged temperature difference ΔT_(off) at S1 and the fall time temperature difference ΔT_(F) between the averaged temperature difference ΔT_(off) at S1 and the averaged temperature difference ΔT_(on) at S2 are determined.

The flow, F_(R), is calculated for each data collection cycle from the known amount of power P introduced into the blood flow stream by the energy source, or heater 21, from the known heat capacitance of blood, C_(P), and from the difference in the averaged temperature differences ΔT_(on) and ΔT_(off), which occurs over the data collection cycle S1+D1+S2 in accordance with the following relationship: ##EQU2## In a similar manner, the flow F_(F) is calculated from P, C_(P) and the difference in the averaged temperature differences ΔT_(on) and ΔT_(off) which occurs over the later portion of the data collection cycle S1÷D1+S2 in accordance with the following relationship: ##EQU3## F_(R) and F_(F) can be averaged to obtain the averaged flow (F) over one data collection cycle as shown in FIG. 6. ##EQU4## A suitable calibration constant can be used to adjust the values of F_(R), F_(F) and F.

Accordingly, by using two temperature sensors 19 and 20, cardiac output can be determined several times a minute in accordance with FIGS. 3-6, yielding an effectively continuous cardiac output value. Because such measurements can be made using relatively low power levels, the danger that the heart may be damaged by the introduction of thermal energy is substantially eliminated.

It will be apparent that the foregoing technique, which has been described in connection with the direct introduction of heat as an indicator agent and the measurement of temperature, can readily be performed by those skilled in the art by using indicator agents which affect the pH of the blood or change other blood parameters.

In some situations it may be desirable to provide more frequent indications of cardiac output, such as, for example, the instantaneous cardiac output or the cardiac output averaged over each individual cardiac cycle (i.e. each heart beat). Such information can be provided using the further embodiments of the invention discussed below with reference to FIGS. 7-8. A single temperature sensor 30 at a location near the distal end of the catheter 31 (as shown in FIG. 7A) can be used to determine the instantaneous or beat-to-beat blood velocity V(t). The blood velocity can be combined with the cardiac output averaged over one or more data collection cycles to calculate instantaneous cardiac output. The process used is shown in the process depicted in FIG. 7B, identified as Process IV.

As seen therein, the initial temperature T_(3i) (t) sensed at temperature sensor 30 as a function of time is smoothed, or filtered, in the manner as previously discussed above, and suitably measured and stored at an initial time t₀. A predetermined rise in temperature ΔT₃ of the temperature sensor itself is selected. Power is then supplied at time t₀ to the temperature sensor 30 from a power source 30A connected thereto to cause its temperature T₃ (t) to rise by a predetermined amount.

Power may be supplied to the sensor in different ways according to the needs of the particular measurement and the relative simplicity or complexity of the required circuitry, three such ways being depicted in FIGS. 8A, 8B, and 8C.

For example, in a first mode of operation (FIG. 8A), heating power may be supplied to the sensor in such a manner as to keep the final sensor temperature T_(3f) (t) constant at an initial level ΔT₃ above the initial temperature T_(3i) (t₀), i.e. T_(3f) =T_(3i) (t₀)+ΔT₃ even when the local blood temperature varies with time, as illustrated in FIG. 9A. Under such conditions, the sensor is maintained at a time-varying temperature increment ΔT₃ (t) above the instantaneous local blood temperature, T_(b) (t).

Alternatively, in a second mode of operation, power can be supplied to the sensor so as to continuously maintain the sensor at a fixed temperature increment above the time varying local blood temperature, as illustrated in FIG. 9B. Under such conditions, ΔT₃ (t)=ΔT₃, a constant, and the sensor temperature varies according to T_(3f) (t)=ΔT₃ +T_(3i) (t).

A third mode of heating may also be convenient when the temperature sensors are temperature-sensitive resistors, or thermistors. Thus, when a thermistor is used, it may be more convenient to design an electrical heating circuit that maintains the sensor at a constant resistance increment above the resistance of the sensor that corresponds to the local blood temperature. If R is the corresponding resistance for a sensor temperature T, then these conditions are represented by ΔR₃ (t)=ΔR₃, a constant, and the sensor resistance varies according to R_(3f) (t)=ΔR₃ +R_(3i) (t), as illustrated in FIG. 9C. The change in temperature ΔT₃ (t) is then replaced by the change in resistance R₃ (t) in the ratio which is integrated over a cardiac cycle. Further details and exemplary apparatus for such modes of operation are presented and described in U.S. Pat. No. 4,059,982, issued to E. F. Bowman on Nov. 29, 1977. With all three of the above approaches, power (P) is supplied to produce a temperature rise (ΔT) both of which are then related to the instantaneous blood velocity and, hence, blood flow.

Techniques in which sensor heating power and temperature can be measured and used to provide more detailed information on cardiac output are described below. The technique involved can be applied to measure both instantaneous cardiac output, and the cardiac output for an individual cardiac cycle. Such detailed measurement information greatly enhances the diagnostic capability of a physician.

First, a method is described to measure instantaneous volumetric flow (which flow if measured at the location described above is the cardiac output). For each of the particular implementations described above, the power P₃ (t) applied to the temperature sensor 30 is controlled so as to maintain the final temperature of the sensor at a desired value T_(3f). The power applied to the temperature sensor 30 or, more generally, the ratio of the power applied to the sensor to the temperature increment, P₃ (t)/ΔT₃ (t), is directly correlated with the fluid and flow properties of the flowing liquid about the sensor.

For example, the relationship between required sensor power and local fluid velocity, V(t), is given by a correlation of the form:

    P(t)=4πkaΔT(t)  1+C.sub.1 P.sub.r.sup.n (2aρ V(t)/μ).sup.m!

Where

P(t)=instantaneous power to sensor

k=thermal conductivity of fluid

a=sensor radius

ΔT(t)=instantaneous temperature difference between heated sensor and unheated fluid temperature.

C₁ =constant of calibration

P_(r) =a non-dimensional "Prandtl" number which relates to the viscosity μ, heat capacity Cp and thermal conductivity k of a fluid.

n,m=power factors which are determined from experimental data

ρ=fluid density

μ=viscosity

V(t)=instantaneous fluid velocity

The fluid flow velocity in the vicinity of the sensor can be determined from the required sensor heating power. Volumetric flow in the vessel can then be determined with one further assumption for the distribution of the fluid flow within the vessel. For example, assuming a uniform velocity profile within the vessel, volumetric flow F₃ is given by

    F.sub.3 =V A

where V is the fluid velocity in the vessel and A is the flow area. If the fluid flow area A is not previously known, it may be inferred from the measurement of average volumetric flow in the vessel. Such average volumetric flow can be determined, for example, by using the techniques of the invention already described above herein or by using other techniques for yielding comparable information. For example, if F is the average cardiac output, typically measured over several cardiac cycles, as described above, and V is the average fluid velocity, determined by calculating an average value for the instantaneous flow velocity over at least one cardiac cycle, then one such estimate for the average flow area A is given by

    A=F/V

Therefore, given the sensor measured heating power, first the fluid velocity and then volumetric flow can be calculated at any desired instant in time, i.e., F₃(t)= V(E)A, yielding an instantaneous measure of volumetric flow, i.e., cardiac output.

In another embodiment, a method to measure cardiac output over a single cardiac cycle is described. As described above in different implementations, the power P₃ (t) applied to the temperature sensor 30 is controlled so as to maintain the temperature of the sensor at a desired signal value T_(3f). The power applied to the temperature sensor 30, or more generally, as discussed above, the ratio of the power applied to the sensor to the temperature increment, i.e., P₃ (t)/ΔT₃ (t), is directly correlated with the properties of the fluid flow in the vicinity of the sensor. Thus, the integrated value of the power to temperature ratio over a single cardiac cycle is directly correlated with, i.e., is proportional to the average cardiac output over the cardiac cycle, ##EQU5## or, alternatively expressed ##EQU6## where T represents the period of the cardiac cycle and F correspondingly represents cardiac output averaged over the cardiac cycle. Thus, the average cardiac output Fover an individual cardiac cycle then can be determined from the measured and integrated power and temperature signals from the sensor.

Furthermore, an explicit correlation for integrated power and average cardiac output over the cardiac cycle may be dispensed with if a simple qualitative indication of the change in cardiac output on a cardiac cycle-to-cardiac cycle basis is desired. To obtain such information, a given measurement of cardiac output is taken as associated with a corresponding measured value of the integrated sensor signal over a cardiac cycle. The measurement of cardiac output could be obtained intermittently by the techniques described in this invention or other similar techniques. Since cardiac output is known to be correlated with the value of the integrated sensor signal over the cardiac cycle, any changes in the sensor signal indicate a corresponding change in cardiac output.

In certain situations, it may be desirable to compensate for temperature variations in the blood which is flowing past the sensor, as this may affect the value of F(t). A process for such compensation is depicted as Process IV in FIG. 7B wherein a temperature T₂ (t) is sensed by a second sensor (which may be, for example, sensor 19 or sensor 20) at a location remote from sensor 30 (see FIG. 7A). For example, knowledge of the instantaneous blood temperature is required for the process in which the heated sensor is maintained at a constant increment above the local blood temperature. In this case, the temperature T₂ (t) is used as a proxy for the temperature T₃ (t) which would be measured in the absence of sensor heating.

In a further alternative embodiment, where only two sensors 19 and 20 are utilized (as shown in FIG. 2), sensor 20 can be used as the primary sensor when calculating instantaneous cardiac output (equivalent to sensor 30 in FIG. 7A) and sensor 19 can be used as the secondary temperature compensation sensor. In such an embodiment, the averaged cardiac output can be determined using sensors 19 and 20, as set forth in FIGS. 3-6 and the instantaneous cardiac output can then subsequently be determined using sensors 19 and 20, as set forth in FIG. 7B and either FIGS. 8A, 8B or 8C, such average and instantaneous cardiac output determinations being made in sequence by the microprocessor to provide the cardiac information in both forms, as desired.

As mentioned above, when using the above described catheter, the various flow values which are determined in accordance with the processes as discussed above are proportional to flow but may not be equal to the actual flow values unless they are suitably calibrated since the correspondence between the calculated and actual values depends on the manner in which a particular catheter is constructed and used. A calibration constant for a particular catheter can be represented by the slope and intercept of a curve which relates the calculated flow and the actual flow, in accordance with the following relationship:

    F.sub.actual =aF.sub.calc. +b

where, as illustrated in FIG. 10, "a" is the slope of a straight line 35 and "b" is the intercept thereof along the vertical axis. Curve 35 can be obtained by using a known catheter and known flow values therein to construct a curve 36. The best straight line fit is determined as line 35. The slope "a" and intercept "b" are thereby determined. Such determined values for "a" and "b" can be used with the calculated flow values in each case to determine the actual flow from the calculated flow.

While the above description discusses preferred embodiments of the invention, modifications thereof may occur to those in the art within the spirit and scope of the invention. Hence, the invention is not to be construed as limited to particular embodiments described, except as defined by the appended claims. 

What is claimed is:
 1. A system for determining blood flow in a living body comprising:means for changing the thermal energy level by a predetermined amount at a site in a blood flow path of said living body; means for detecting the temperatures at a first location upstream of said site and a second location downstream of said site; means for determining the temperature difference between said first and second locations at one energy level; means for determining the temperature difference between said first and second locations at a changed energy level; and means for calculating blood flow as a function of the change in energy level and of the temperature differences measured prior to and following the change in energy level.
 2. A system in accordance with claim 1 wherein said first location is substantially thermally isolated from thermal energy changes occurring at said site.
 3. A system in accordance with claim 2 wherein said blood flow path includes at least a portion of the heart of a living body and the blood flow represents cardiac output.
 4. A system in accordance with claim 3 wherein said site is at least partially in the right atrium of the heart, said first location is in the vena cava of the heart, and the second location is in or near the pulmonary artery of the heart.
 5. A system in accordance with claim 3 wherein said site is at least partially the right atrium of the heart, said first location is in the vena cava of the heart, and the second location is in or near the right ventricle of the heart.
 6. A system in accordance with claims 1, 2, 3, 4 or 5 wherein said system includes a catheter, said thermal energy changing means is a thermal energy source carried by said catheter and positioned in the blood flow path, and said temperature detecting means are temperature sensors positioned in said catheter so that when said catheter is positioned in said blood flow path said thermal energy source is at said site and said temperature sensors are at said first and second locations, respectively.
 7. A system for determining blood flow in a living body comprising:means for changing the thermal energy at a site in a blood flow path of said living body, from a first level to a second level; means for determining a characteristic of the temperature difference between the temperatures in said blood flow path at a first location upstream of said site and at a second location downstream of said site at said first level; means for determining a characteristic of the temperature difference between the temperatures in said blood flow path at the first location and at the second location at said second level; means for determining the difference between the characteristics of said temperature differences; means for calculating blood flow as a function of the difference between the characteristics of said temperature differences and the change in thermal energy from said first level to said second level.
 8. A system in accordance with claim 7 wherein said characteristic determining means determines said characteristics over a specified time period.
 9. A system in accordance with claim 8 wherein each of said characteristics is the average of the temperature differences.
 10. A system in accordance with claim 8 wherein the specified time period is at least one respiratory cycle.
 11. A system in accordance with claims 7, 8, 9 or 10 wherein said blood flow path includes at least a portion of the heart of a living body where the blood flow represents cardiac output.
 12. A system in accordance with claim 11 wherein said site is at least partially in the right atrium of the heart, said first location is in the vena cava of the heart, and the second location is in or near the pulmonary artery of the heart.
 13. A system in accordance with claim 11 wherein said site is at least partially in the right atrium of the heart, said first location is in the vena cava of the heart, and the second location is in or near the right ventricle of the heart.
 14. A system in accordance with claim 7 wherein each of said characteristic temperature difference determining means includes:means for detecting temperatures at said first location upstream of said site and at said second location downstream of said site during each cycle of one or more respiratory cycles, when said thermal energy is at said first level and when said thermal energy is at said second level; means for determining temperature differences between said temperatures for each respiratory cycle, when said thermal energy is at said first level and when said thermal energy is at said second level; and means for determining the average of said temperature differences over multiple respiratory cycles.
 15. A system in accordance with claim 7 wherein:said thermal energy level changing means includes means for applying a predetermined amount of power P at said site to change said thermal energy level from said first level to said second level; and said cardiac output calculating means includes means for calculating a rise-time cardiac output component as a function of the power P, the calculated average rise-time temperature difference, and the heat capacity of blood; means for calculating a fall-time cardiac output component as a function of the power P, the calculated fall-time difference, and the heat capacity of blood; and means for calculating the cardiac output as a function of the rise-time and fall-time cardiac components.
 16. A system in accordance with claims 7, 8, 9 or 10 wherein said system calculates the cardiac output repeatedly to provide an effectively continuous calculation thereof.
 17. A system in accordance with claim 16 and further including means responsive to the repeated calculations of the cardiac output can for averaging said calculation over a selected number of repeated calculations to provide an averaged cardiac output over said selected number of calculations.
 18. A system for determining blood flow in a living body comprising:means for changing the value of a selected parameter of blood at a site in the blood flow path of said living body, from a first level to a second level; means for determining the difference between the value of the selected parameter in said blood flow path at a first location upstream of said site and at a second location downstream of said site at said first level; means for determining the difference between the value of the selected parameter in said blood flow path at the first location and at the second location at said second level; means for determining the difference between the value determined by the first said difference determining means and the value determined by the second said difference determining means; and means for calculating blood flow as a function of the difference determined by the third said difference determining means and the change in the value of the selected parameter produced by said changing means.
 19. A system in accordance with claim 18 wherein said blood flow path includes at least a portion of the heart of a living body where the blood flow represents cardiac output.
 20. A system for determining blood flow in a living body comprising:catheter means adapted to be located in a blood flow path of a living body; means at a site along said catheter for changing the value of a selected parameter of blood; signal means at a location on said catheter downstream of said site and responsive to the value of said parameter for providing a first signal functionally related thereto; signal means for providing a reference signal; and means responsive to said first and reference signals when said selected parameter has one value and when said selected parameter has a changed value and further responsive to the output of said changing means for producing a signal proportional to blood flow.
 21. A system according to claim 20 wherein said changing means comprises an electrically energizable heater on said catheter for changing the temperature of blood flow in said blood flow path.
 22. A system according to claim 21 wherein said downstream signal means comprises a first thermistor.
 23. A system according to claim 21 or 22 wherein said reference signal means comprises a second thermistor on said catheter upstream of said changing means.
 24. A system for determining blood flow in a living body comprising:means for changing the temperature of blood at a site in the blood flow path of a living body; first thermistor means at a first location relative to said site responsive to the temperature of blood; second thermistor means at a location downstream of said site responsive to the temperature of blood; means responsive to both said first and second thermistor means for producing a difference signal functionally related to the difference in the temperatures at said first and downstream locations; and means for generating a signal proportional to blood flow as a function of a temperature difference signal between said first and downstream locations obtained prior to a temperature change induced by said changing means and of a temperature difference signal between said first and downstream locations obtained subsequent to a temperature change induced by said changing means and further as a function of the output of said changing means.
 25. A system according to claim 24 wherein said first location is upstream of said site.
 26. A system according to claim 24 wherein said changing means comprises electrically energizable heater means.
 27. A system for determining blood flow in a living body comprising:(a) means for changing the thermal energy of blood at a site in a blood flow path of the living body from an initial condition to a changed condition; (b) means for determining a first difference in temperatures in the blood flow path between a first location upstream of said site and a second location downstream of said site when the thermal energy of blood at said site is at said initial condition; (c) means for determining a second difference in temperatures in the blood flow path between the first location and the second location when the thermal energy of blood at said site is at said changed condition; (d) means for producing a signal functionally related to the change in said first and second temperature differences; and (e) means for calculating blood flow as a function of the signal produced by said producing means and the output of said changing means.
 28. A system for determining blood flow in the blood flow path of a living body comprising:(a) means for changing the thermal energy of blood at a site in the blood flow path between initial and changed conditions; (b) means for determining temperature differences in the blood flow path between a location upstream of said site and a location downstream of said site; and (c) means for calculating blood flow as a function of the temperature differences determined when the thermal energy of blood is at said initial condition, as a function of the change in temperature determined when the thermal energy of blood is at said changed condition, and as a function of the changes produced by said changing means.
 29. A system according to claim 28 wherein said changing means comprises means for repeatedly cycling between initial and changed conditions and wherein said calculating means comprises means for repeatedly making said calculation for each of several cycles produced by said changing means to provide a substantially continuous blood flow calculation.
 30. A system according to claim 28 or 29 further comprising:means for determining the differences between the temperature differences determined when the thermal energy of blood is at initial conditions and the temperature differences determined when the thermal energy of blood is at changed conditions; and means for calculating blood flow as a function of changes in the thermal energy produced by said changing means and said differences between the temperature differences.
 31. A system for determining blood flow in the blood flow path of a living body comprising:means for changing the value of a characteristic of blood at a site in the blood flow path; means for providing a first signal having a value functionally related to the characteristic of blood in the blood flow path at a location downstream of said site; means for providing a second signal having a value corresponding to the characteristic of blood at a location in the blood flow path sufficiently upstream of said site to be substantially unaffected by said changing means; and means for calculating blood flow as a function the values of said first and second signals and the change produced by said changing means.
 32. A system in accordance with claim 31 wherein said calculating means further comprises:means for determining first differences between said first and second signals when one value obtains and second differences between said first and second signals when a changed value obtains; means for ascertaining differences between said first and second differences; and means for calculating blood flow as a function of the differences of said differences ascertained by said ascertaining means and the change introduced by said changing means.
 33. A system according to claim 31 or 32 wherein said changing means comprises a heater and said characteristic is temperature.
 34. A system according to claim 33 wherein said first and second signal providing means comprise first and second thermal sensors, respectively, and wherein said second thermal sensor is located upstream of said site.
 35. A system for determining blood flow in the blood flow path of a living body comprising:means for changing a thermal energy characteristic of blood at a site in the blood flow path between a first condition and a second condition; means for providing a first signal functionally related to the change in the thermal energy characteristic of blood in the blood flow path produced by said changing means; means for providing a second signal representing the thermal energy characteristic of blood in the blood flow path substantially unaffected by change produced by said changing means; and means for calculating blood flow as a function of the difference in the value of said first and second signals when the blood in said blood flow path is characterized by the first condition produced by said changing means, the difference in the value of said first and second signals when the blood in said blood flow path is characterized by the second condition produced by said changing means, and the output of said changing means.
 36. A system according to claim 35 wherein said second signal providing means comprises means for detecting the thermal energy characteristic of blood in the blood flow path at a location upstream of and substantially thermally isolated from said site.
 37. A system according to claim 35 or 36 wherein said first signal providing means comprises a thermal sensor at a location in said blood flow path downstream of said site.
 38. A system for determining blood flow in the blood flow path of a living body comprising:means for supplying indicator agent at known rates at a site in the blood flow path for producing one or more cycles of increases and decreases in the effect of said agent; means responsive to indicator agent in said blood flow path at a first location downstream of said site for producing a signal having a value variable in accordance with variation in the effect of indicator agent at said first location; means responsive to indicator agent in said blood flow path at a second location upstream of said site for producing a signal having a value variable in accordance with variation in the effect of indicator agent at said second location; means for determining differences in said signals produced at said first and second locations; and means for calculating blood flow as a function of the indicator agent supplied by said supplying means and the differences determined by said determining means.
 39. A system according to claim 38 further comprising means for producing repeated calculations of blood flow to provide effectively continuous calculation thereof.
 40. A system in accordance with claim 39 wherein said means for producing repeated calculations produces each repetition over one or more respiratory cycles.
 41. A system for determining blood flow in the blood flow path of a living body comprising:heating means adapted to be located at a site in the blood flow path; means for supplying a known amount of power to said heating means for producing a repeating pattern of temperature rises and temperature falls; means responsive to thermal energy in said blood flow path at a location downstream of said site for producing a downstream signal having a value variable in accordance with variation in the temperature at said downstream location; means responsive to thermal energy in said blood flow path at a location upstream of said site for producing an upstream signal having a value variable in accordance with variation in the temperature at said upstream location; means for determining differences in said upstream and downstream signals for each of a succession of repetitions of said patterns of temperature rises and temperature falls; and means for substantially continuously calculating blood flow as a function of the power supplied by said supplying means over each of said succession of repetitions and the output of said determining means over each of said succession of repetitions.
 42. A system for determining blood flow in the blood flow path of a living body comprising:means for introducing a known amount of an agent at a site in the blood flow path to change values of a selected parameter of the blood; means for detecting values of said parameter in said blood flow path at a first location downstream of said site; means for detecting values of said parameter in said blood flow path at a second location upstream of said site where introduced agent is not substantially detectable; means for determining the differences in the values detected at said first and second locations over intervals when the introduced agent is detectable at said first location and when the introduced agent is not substantially detectable at said first location; and means for calculating blood flow as a function of the amount of agent introduced by said introducing means, the differences in the values of the parameter detected at the first and second locations when the introduced agent is detectable at said first location, and the differences in the values of the parameter detected at the first and second locations when the introduced agent is not substantially detectable at said first location.
 43. A system according to claim 42 wherein said introducing means is a heater and said detecting means are thermal sensors.
 44. A system for determining blood flow in a living body comprising a pair of thermal sensors spaced apart in the blood flow path; means for introducing a known thermal energy input into the blood flow path at a location between said thermal sensors;means for determining temperature differences between said sensors over one or more respiratory cycles; and means for calculating blood flow as a function of the output of said introducing means, the temperature differences determined by said determining means during a period when the blood temperature at the downstream sensor is affected by the output of said introducing means, and the temperature differences determined by said determining means when the blood temperature at the downstream sensor is not substantially affected by the output of said introducing means.
 45. A system according to claim 44 wherein said introducing means is an electrical resistance heater.
 46. A system for determining blood flow in the blood flow path of a living body comprising:means for introducing into a site in the blood flow path a factor to change a value of a selected parameter of blood; means for determining a first signal as a function of the value of the parameter at a location downstream of said site as the value of said parameter changes at the downstream location as a result of the change introduced at said site by said introducing means; means for detecting the value of the selected parameter at a location in said blood flow path upstream of said site when the first signal is being determined by said determining means; and means for producing a signal proportional to blood flow as a function of said first signal, the value detected by said detecting means, and the output of said introducing means.
 47. A system in accordance with claim 46 wherein said introducing means comprises means for introducing thermal energy and said determining means comprises a thermal sensor.
 48. A system in accordance with claim 47 wherein said detecting means comprises a thermal sensor in said blood flow path upstream of said site.
 49. A system for determining blood flow in the blood flow path of a living body comprising:means for introducing a known amount of an indicator agent at a site in the blood flow path; means for detecting values associated with indicator agent in the blood flow path at a first location downstream of said site during an interval including substantially the time from the start of introduction of the agent until the introduced agent has cleared the site; means for detecting values associated with indicator agent in the blood flow path during said interval at a second location upstream of said site effectively isolated from the effects of indicator agent introduced by said introducing means; means for determining a difference signal between values detected at said first and second locations during said interval; means for integrating said difference signal over said interval; and means for calculating blood flow as a function of the output of said introducing means and the output of said integrating means.
 50. A system according to claim 49 wherein said introducing means comprises means for introducing thermal energy and said upstream and downstream detecting means comprise upstream and downstream thermal sensors, respectively, said upstream sensor being substantially thermally isolated from said site.
 51. A system for determining blood flow in the blood flow path of a living body comprising:(a) means for supplying indicator agent at known rates at a site in the blood flow path over an interval of one or more respiratory cycles in duration for producing cyclical increases and decreases in the effect of indicator agent during said interval; (b) means for detecting values associated with indicator agent in the blood flow path at a first location downstream of said site; (c) means for detecting values associated with indicator agent in the blood flow path at a second location upstream of said site; (d) means for determining differences between values detected at said first and second locations; (e) means for detecting the effects of respiratory cycles on the output of said determining means; (f) means for processing the effects detected by said effects detecting means to produce a processed signal; and (g) means for calculating blood flow as a function of the output of said supplying means and the processed signal.
 52. A system according to claim 51 wherein said processing means comprising means for filtering the effects of respiratory cycles out of the output of said determining means.
 53. A system according to claim 52, further comprising:(a) means for recognizing the duration of each respiratory cycle in the series of respiratory cycles; and (b) means for causing said supplying means to produce cyclical increases and decreases in the effect of indicator agent over a series of respiratory cycles; (c) wherein said processing means comprises means for obtaining an average of the differences determined by said determining means over each respiratory cycle.
 54. A system according claims 51, 52 and 53 wherein said supplying means comprises a heater and each of said values detecting means comprises a thermal sensor.
 55. A system for determining blood flow in the blood flow path of a living body comprising:(a) means for supplying indicator agent at known rates at a site in the blood flow path over an interval including a series of respiratory cycles for producing cyclical increases and decreases in the effect of indicator agent during said interval; (b) means for detecting values associated with indicator agent in the blood flow path at a location downstream of said site; (c) means for providing reference values substantially unaffected by the output of said supplying means; (d) means for determining differences between the first said values and said reference values; (e) means for detecting the effects of respiratory cycles on the difference values determined by said determining means during said interval; (f) means for processing the output of said detecting means to produce a processed signal; and (g) means for calculating blood flow as a function of the output of said supplying means and the processed signal produced by said processing means.
 56. A system according to claim 55 wherein said reference values providing means comprises means for providing values corresponding to the value associated with indicator agent in the blood flow path at a location substantially unaffected by the output of said supplying means.
 57. A system according to claim 55 wherein said supplying means comprises a heater and said values detecting means comprises a thermal sensor.
 58. A system according to claim 57 wherein said reference value providing means comprises a thermal sensor for detecting values associated with indicator agen in said blood flow path at a location upstream of said site.
 59. A claim according to claim 57 wherein said processing means comprises means for filtering the effects of respiratory cycles from the output of said determining means to produce a filtered signal.
 60. A claim according to claim 59 wherein said filtering means comprises:(a) means for recognizing the duration of each respiratory cycle in the series of respiratory cycles; and (b) means for obtaining an average value over each respiratory cycle of the output of said determining means.
 61. A system according to claims 55, 56, 58, or 60 wherein said supplying means further comprises means for producing cyclical increases and decreases in the effect of indicator agent characterized by intervals of substantially equal duration, alternating between a base value of indicator agent and a value of indicator agent above the base value. 